Prehospital Blood Pressure and Clinical and Radiological Outcomes in Acute Spontaneous Intracerebral Hemorrhage.
Larsen KT, Selseth MN, Jahr SH, Hillestad V, Koubaa N, Sandset EC, Rønning OM, Kristoffersen ES. Stroke 2022. PMID: 36252098

Incidence and Mortality of Cerebral Venous Thrombosis in a Norwegian Population.
Kristoffersen ES, Harper CE, Vetvik KG, Zarnovicky S, Hansen JM, Faiz KW. Stroke. 2020. PMID: 32883194

Does implementation of a standardized pathway of stroke care affect functional outcome after stroke?
Bergh E, Askim T, Rønning OM, Šaltytė Benth J, Fjærtoft H, Thommessen B. Int J Stroke. 2023. PMID: 36300753.

Early versus Later Anticoagulation for Stroke with Atrial Fibrillation.
ELAN Investigators including Kristoffersen ES and Rønning OM. N. Engl. J. Med 2023. PMID: 37222476

Intravenous Thrombolysis in Patients With Ischemic Stroke and Recent Ingestion of Direct Oral Anticoagulants.
Meinel TR, Wilson D, Gensicke H, Scheitz JF, Ringleb P, Goganau I, Kaesmacher J, Bae HJ, Kim DY, Kermer P, Suzuki K, Kimura K, Macha K, Koga, Wada S, Altersberger V, Salerno A, Palanikumar L, Zini A, Forlivesi S, Kellert L, Wischmann J, Kristoffersen ES, Beharry J, Barber A, Hong JB, Creda C, Schlemm E, Yakushiji Y, Poli S, Leker R, Romoli M, Zedde M, Curtze S, Ikenberg B, Uphaus T, Giannandrea D, Portela PC, Veltkamp R, Ranta A, Arnold M, Fischer U, Cha JK, Wu TY, Purrucker JC, Seiffge DJ. Jama Neurol 2023. PMID: 36807495

Antithrombotic treatment after stroke due to intracerebral haemorrhage.
Cochrane A, Chen C, Stephen J, Rønning OM, Anderson CS, Hankey GJ, Al-Shahi Salman R. Cochrane Database Syst Rev 2023. PMID: 9878977

Prediction of occult atrial fibrillation in patients after cryptogenic stroke and transient ischaemic attack: PROACTIA.
Skrebelyte-Strøm L, Rønning OM, Dahl FA, Steine K, Kjekshus H. Europace 2022. PMID: 35819199

Effects of oral anticoagulation in people with atrial fibrillation after spontaneous intracranial haemorrhage (COCROACH): prospective, individual participant data meta-analysis of randomised trials.
Al-Shahi Salman R, Stephen J, Tierney JF, Lewis SC, Newby DE, Parry-Jones AR, White PM, Connolly S, Benavente OR, Dowlatshahi D, Cordonnier C, Viscoli CM, Sheth KN, Kamel H, Veltkamp R, Larsen KT, Hofmeijer J, Kerkhoff H, Schreuder F, Shoamanesh A, Klijn CJM, Van der Worp B.
Lancet Neurol 2023. PMID: 37839434

Iselin -The Norwegian Cerebral Venous Thrombosis study (NoCVT) - a long-term follow-up

Silje - Fast track ischemic stroke patients. A study of prehospital and intrahospital predictors of thrombolysis and functional outcome. The Akershus Study of Ischemic Stroke and Thrombolysis-1 (ASIST-1)

Maiken - Large vessel occlusion in a Norwegian population, imaging-based treatment selection and functional prognosis after stroke. The Akershus Study of Ischemic Stroke and Thrombolysis-1 (ASIST-1)

• 2016- STATICH Study of Antithrombotic Treatment after Intracerebral Haemorrhage Multisenterstudie (Ahus, OUS). Prosjektansvarlige: Ole Morten Rønning/Torgeir Brun Wyller. (Sponsor: Oslo University Hospital)
• 2022- OCEANIC-STROKE Oral faCtor Eleven A iNhibitor asundexIan as novel anti-thrombotiC –STROKE study (Sponsor: Bayer)
• 2022- Cerebral venous thrombosis i en norsk populasjon (NoCVT) (Sponsor: Ahus)
• 2017- The Akershus aCute Headache Evaluation 1 (ACHE-1) study. Epidemiology, clinical presentation, treatment and follow-up of subarachnoid haemorrhage in a Norwegian population
• 2017- Epidemiology, clinical and radiological presentation of cerebral venous thrombosis in a Norwegian population
• 2017- The Akershus Study of Ischemic Stroke and Thrombolysis 1 (ASIST-1)
• 2013-2016 NOR-TEST The Norwegian Tenecteplase Stroke Trial 2 Randomised Trial of Tenecteplase vs. Alteplase in Acute Ischemic Stroke (Sponsor: Haukeland University Hospital)
• 2017-2021 TWIST Tenecteplase in Wake-up Ischaemic Stroke Trial (Sponsor: University of Northern Norway)
• 2020-2022 AXIOMATIC Oral Factor XIa Inhibitor, for the Prevention of New Ischemic Stroke or New Covert Brain Infarction in Patients Receiving Aspirin and Clopidogrel Following Acute Ischemic Stroke or Transient Ischemic Attack (Sponsor: Bristol Myers Squibb)
• 2021-2023 ELAN Early versus Late initiation of direct oral Anticoagulants in post-Ischaemic stroke patients with atrial fibrillatioN (Sponsor: University Hospital Bern)

• 2016 - Joint analysis of the Swiss and Norwegian Stroke Registries, led by Ole Morten Rønning, Norway and David Seiffge, Bern, Switzerland
• 2017 - Collaboration of Controlled Randomised Trials of Long-Term Oral Antithrombotic Agents After Spontaneous Intracranial Haemorrhage (COCROACH), led by Rustam Al-Shahi Salman, Edinburgh, UK. Participation by Rønning and Larsen
• 2017 – ACHE-1 The Akershus aCute Headache Evaluation 1 study. Epidemiology, clinical presentation, treatment and follow-up of subarachnoid haemorrhage in a Norwegian population (Sponsor: Akershus University Hospital)
• 2018 - NoCVT Epidemiology, clinical and radiological presentation and prognosis of cerebral venous thrombosis in a Norwegian population (NoCVT) (Sponsor: Akershus University Hospital)
• 2020 – NoICH Intracerebral Haemorrhage in a Norwegian population - a prospective long-term follow-up study (Sponsor: Akershus University Hospital)
• 2021- ExBiCVT Exploring the biology, treatment and prognosis of cerebral venous thrombosis (Sponsor: Akershus University Hospital)
• 2021 – ICVTC International Cerebral Venous Thrombosis Consortium led by Jonathan Couthino, Netherland
• 2021 – CVT-VITT Study Group CVT post-vaccine studies led by Jonathan Couthino, Netherland
• 2021 - CVT-AIM CVT and Autoimmune diseases, led by Dr. Sini Hiltunen, Helsinki, Finland
• 2022 – ICEBERG Imaging to CharacterizE Brain spontaneous & trauma hemorrhage, led by Prof. Bradley MacIntosh, Oslo, Norway and Toronto, Canada
• 2023 - READOUT-ICH (Real-time radiology support to treat intracerebral hemorrhage), led by Prof. Bradley MacIntosh, Oslo, Norway and Toronto, Canada
• 2023 - DO-IT target trial A retrospective follow-up study of thrombolysis in patients with recent DOAC ingestion, led by Thomas Meinel and prof. David Seiffge, Bern, Switzerland. National lead by Kristoffersen
• 2023 - DO-IT registry, an international prospective academic registry to capture consecutive patients on DOACs qualifying for IVT, led by Thomas Meinel and prof. David Seiffge, Bern, Switzerland. National lead by Kristoffersen
• 2023 - HEURECA Intracerebral Hemorrhage Recurrence Alliance, led by prof. David Seiffge, Bern, Switzerland

• 2013-2016 NOR-TEST The Norwegian Tenecteplase Stroke Trial 2 Randomised Trial of Tenecteplase vs. Alteplase in Acute Ischemic Stroke (Sponsor: Haukeland University Hospital)

https://www.thelancet.com/journals/laneur/article/PIIS1474-4422(17)30253-3/fulltext

• 2017-2021 TWIST Tenecteplase in Wake-up Ischaemic Stroke Trial. A multicentre, open-label, randomised controlled trial. (Sponsor: University of Northern Norway)

https://www.thelancet.com/journals/laneur/article/PIIS1474-4422(22)00484-7/fulltext

• 2019-2021 NOR-TEST 2 Tenecteplase versus alteplase for the management of acute ischaemic stroke in Norway (NOR-TEST 2, part A): a phase 3, randomised, open-label, blinded endpoint, non-inferiority trial (Sponsor: Haukeland University Hospital)

https://www.thelancet.com/article/S1474-4422(22)00124-7/fulltext

• 2020-2022 AXIOMATIC Oral Factor XIa Inhibitor, for the Prevention of New Ischemic Stroke or New Covert Brain Infarction in Patients Receiving Aspirin and Clopidogrel Following Acute Ischemic Stroke or Transient Ischemic Attack (Sponsor: Bristol Myers Squibb)

https://www.thelancet.com/journals/laneur/article/PIIS1474-4422(23)00403-9/fulltext

• 2021-2023 ELAN Early versus Later initiation of direct oral anticoagulants in post-ischaemic stroke patients with atrial fibrillation (Sponsor: University Hospital Bern)

https://www.nejm.org/doi/10.1056/NEJMoa2303048

• 2020-2023 StrokePan Stroke during a pandemic, PI Kristoffersen, (Sponsor: Akershus University Hospital)
• 2020-2023 The Global COVID-19 Stroke Registry led by Raul Nogueira, Pittsburg and Thanh Nguyen, Boston, US. PI Kristoffersen
• 2021 – 2022 The Global COVID-19 CVT Registry led by Thanh Nguyen, Boston, US. PI Kristoffersen
• 2022 – International DOAC-IVT, led by David Seiffge, Bern, Switzerland. PI Kristoffersen

Jannicke Koldeus-Falch - Stroke of unknown cause: The impact of long-term heart monitoring on stroke recurrence in women. 2024-

Iselin T. S. Dahl -The Norwegian Cerebral Venous Thrombosis study (NoCVT) - a long-term follow-up. 2024-

Silje Holt Jahr - Fast track ischemic stroke patients. A study of prehospital and intrahospital predictors of thrombolysis and functional outcome. The Akershus Study of Ischemic Stroke and Thrombolysis-1 (ASIST-1). 2019-

Maiken N. Selseth - Large vessel occlusion in a Norwegian population, imaging-based treatment selection and functional prognosis after stroke. The Akershus Study of Ischemic Stroke and Thrombolysis-1 (ASIST-1). 2021-

Kristin Tveitan Larsen – Prehospital blood pressure in intracerebral hemorrhage. The Akershus Study of Ischemic Stroke and Thrombolysis-1 (ASIST-1). 2017-

Elin J Bergh - The introduction of the pathway of stroke care from onset of symptoms until 3 months poststroke. Life after stroke study. A Norwegian long-term follow-up project (LAST-long). 2020-

Loreta Skrebelyte-Strøm - PRediction and detection of Occult Atrial fibrillation in patients after acute Cryptogenic stroke and Transient Ischemic Attack. 2015-

Elisabeth Forfang – Study of antithrombotic treatment after intracerebral haemorrhage. 2016-

Chapter in Medisinsk ultralyddiagnostikk, 2016 ISBN: 9788205490178

Utarbeidelse av Nasjonal retningslinjer for hjerneslag (arbeidsgruppeleder)

Fagansvarlig for kapittel om Hjerneslag i NEVRONEL

Slagskole for slagpasienter med nylig gjennomgått hjerneslag og deres pårørende i Ahus’ opptaksområde

We provide the highest level of stroke services (comprehensive stroke center) according to criteria set by the European Stroke Organisation, except for neurosurgery, and serve a catchment area of 600.000 inhabitants, and for thrombectomy a 24/7 service for 1.000.000 inhabitants.

The senior consultants are all experts in stroke medicine, and most have done and are doing research in cerebrovascular projects.

The number of stroke patients, the size of the hospital, the competent staff and the standardized path of stroke treatment facilitates research in stroke. In addition the hospital provides biobank service and a large research department to assist in stroke studies.